Mass spectrometry study of a transferrin-based protein drug reveals the key role of protein aggregation for successful oral delivery

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Mass spectrometry study of a transferrin-based protein drug reveals the key role of protein aggregation for successful oral delivery.

A recently designed human growth hormone/transferrin fusion protein (GHT) remains one of the very few examples of a protein capable of eliciting measurable therapeutic response after oral administration. To better understand the underlying factors that resulted in this rare success of nonparenteral protein drug delivery, we analyzed proteolytic stability and receptor binding properties of this ...

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ژورنال

عنوان ژورنال: Proceedings of the National Academy of Sciences

سال: 2012

ISSN: 0027-8424,1091-6490

DOI: 10.1073/pnas.1206924109